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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1097
http://purl.obolibrary.org/obo/NCIT_C1097
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|---|---|
| Preferred Name | Exemestane |
| Definitions |
An irreversible steroidal aromatase inhibitor, with antiestrogen and antineoplastic activities. Upon oral administration, exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the peripheral aromatization of androgens, including androstenedione and testosterone, to estrogens. This lowers estrogen levels in the blood circulation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An irreversible steroidal aromatase inhibitor, with antiestrogen and antineoplastic activities. Upon oral administration, exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the peripheral aromatization of androgens, including androstenedione and testosterone, to estrogens. This lowers estrogen levels in the blood circulation. |
|---|---|
| prefLabel | Exemestane
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| label | Exemestane
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| CHEBI_ID | CHEBI:4953
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| PDQ_Closed_Trial_Search_ID | 42297
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| code | C1097
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| Has_Target | |
| prefixIRI | NCIT:C1097
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| in_subset |
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| Display_Name | Exemestane
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| Preferred_Name | Exemestane
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| FDA_UNII_Code | NY22HMQ4BX
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C20H24O2
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| Maps_To | Exemestane
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| CAS_Registry | 107868-30-4
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| NSC Number | 713563
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| NCI_Drug_Dictionary_ID | 42297
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| Legacy Concept Name | Exemestane
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| type | |
| ALT_DEFINITION | A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen. It is also being studied in the treatment of other types of cancer. Aromasin causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42297
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| Accepted_Therapeutic_Use_For | Estrogen Receptor-Positive Early Breast Cancer; early and advanced-stage breast cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0851344
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