Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1093 http://purl.obolibrary.org/obo/NCIT_C1093
Preferred Name	Etoposide Phosphate
Definitions	A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)
prefLabel	Etoposide Phosphate
label	Etoposide Phosphate
PDQ_Closed_Trial_Search_ID	42801
code	C1093
Has_Target	http://purl.obolibrary.org/obo/NCIT_C18434
prefixIRI	NCIT:C1093
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 http://purl.obolibrary.org/obo/NCIT_C177383 See more See less
Display_Name	Etoposide Phosphate
Preferred_Name	Etoposide Phosphate
FDA_UNII_Code	528XYJ8L1N
Contributing_Source	CTRP FDA PCDC
Chemical_Formula	C29H33O16P
Maps_To	Etoposide Phosphate
CAS_Registry	117091-64-2
NCI_Drug_Dictionary_ID	42801
Legacy Concept Name	Etoposide_Phosphate
Is_PCDC_GCT_Permissible_Value_For_Variable	http://purl.obolibrary.org/obo/NCIT_C274
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Etopophos blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1331
PDQ_Open_Trial_Search_ID	42801
Accepted_Therapeutic_Use_For	Langerhans cell histiocytosis; Mobilization of peripheral-blood progenitor cells; Multiple myeloma; Neuroblastoma; Non-small lung cancer; Osteogenic sarcoma; Ovarian cancer; Retinoblastoma; Small cell lung cancer; Soft tissue sarcomas Hepatocellular cancer; Hodgkins disease; Hypereosinophilic syndrome; Kaposis sarcoma; Testicular cancer; Thymoma; Thyroid cancer; Uterine cancer; Wilms tumor Acute leukemia; Adrenal cortical cancer; Brain cancer; Chronic lymphocytic leukemia; Choriocarcinoma; Esophageal cancer; Ewings sarcoma; Gastric cancer; Germ cell cancer; Gestational trophoblastic neoplasms
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0059874

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