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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C107683
http://purl.obolibrary.org/obo/NCIT_C107683
|
|---|---|
| Preferred Name | Aprutumab |
| Definitions |
An antibody against the fibroblast growth factor receptor type 2 (FGFR2), with potential antineoplastic activity. Upon administration, aprutumab binds to and inhibits FGFR2, which may result in the inhibition of both FGFR2 phosphorylation and FGFR2-mediated signal transduction pathways. This results in the inhibition of cell proliferation and the induction of cell death of FGFR2-expressing tumor cells. FGFR2, upregulated in many tumor cell types, is a receptor tyrosine kinase, which is essential to tumor cellular proliferation, differentiation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibody against the fibroblast growth factor receptor type 2 (FGFR2), with potential antineoplastic activity. Upon administration, aprutumab binds to and inhibits FGFR2, which may result in the inhibition of both FGFR2 phosphorylation and FGFR2-mediated signal transduction pathways. This results in the inhibition of cell proliferation and the induction of cell death of FGFR2-expressing tumor cells. FGFR2, upregulated in many tumor cell types, is a receptor tyrosine kinase, which is essential to tumor cellular proliferation, differentiation and survival. |
|---|---|
| prefLabel | Aprutumab
|
| label | Aprutumab
|
| NCI_META_CUI | CL451871
|
| PDQ_Closed_Trial_Search_ID | 751593
|
| code | C107683
|
| Has_Target | |
| prefixIRI | NCIT:C107683
|
| in_subset | |
| Preferred_Name | Aprutumab
|
| FDA_UNII_Code | GK8781218Z
|
| Contributing_Source | FDA
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| Maps_To |
Anti-FGFR2 Antibody BAY1179470
Aprutumab
|
| CAS_Registry | 1634620-63-5
|
| NCI_Drug_Dictionary_ID | 751593
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 751593
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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