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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C107386
http://purl.obolibrary.org/obo/NCIT_C107386
|
|---|---|
| Preferred Name | PI3K Inhibitor WX-037 |
| Definitions |
A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor WX-037 specifically inhibits PI3K, which prevents the activation of the PI3K/protein kinase B-mediated signaling pathway. This may result in the inhibition of both tumor cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor WX-037 specifically inhibits PI3K, which prevents the activation of the PI3K/protein kinase B-mediated signaling pathway. This may result in the inhibition of both tumor cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. |
|---|---|
| prefLabel | PI3K Inhibitor WX-037
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| label | PI3K Inhibitor WX-037
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| NCI_META_CUI | CL449597
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| PDQ_Closed_Trial_Search_ID | 750893
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| code | C107386
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| Has_Target | |
| prefixIRI | NCIT:C107386
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| in_subset | |
| Preferred_Name | PI3K Inhibitor WX-037
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| Maps_To | PI3K Inhibitor WX-037
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| NCI_Drug_Dictionary_ID | 750893
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 750893
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| Semantic_Type | Pharmacologic Substance
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