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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1070
http://purl.obolibrary.org/obo/NCIT_C1070
|
|---|---|
| Preferred Name | Iproplatin |
| Definitions |
A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04) |
|---|---|
| label | Iproplatin
|
| prefLabel | Iproplatin
|
| Legacy Concept Name | Iproplatin
|
| in_subset | |
| Preferred_Name | Iproplatin
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | 2C3H9N.2Cl.Pt.2HO
|
| Maps_To | Iproplatin
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| PDQ_Open_Trial_Search_ID | 39183
|
| UMLS_CUI | C0057856
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| FDA_UNII_Code | 5R9F9NE9Z2
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| prefixIRI | NCIT:C1070
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| NCI_Drug_Dictionary_ID | 39183
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1070
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| type | |
| NSC Number | 256927
|
| PDQ_Closed_Trial_Search_ID | 39183
|
| Semantic_Type | Pharmacologic Substance
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| CAS_Registry |
62928-11-4
83291-20-7
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| Delete | Subject | Author | Type | Created |
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