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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C106253
http://purl.obolibrary.org/obo/NCIT_C106253
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|---|---|
| Preferred Name | CXCR4 Peptide Antagonist LY2510924 |
| Definitions |
An inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. |
|---|---|
| prefLabel | CXCR4 Peptide Antagonist LY2510924
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| label | CXCR4 Peptide Antagonist LY2510924
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| PDQ_Closed_Trial_Search_ID | 703819
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| code | C106253
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| Has_Target | |
| prefixIRI | NCIT:C106253
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| in_subset |
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| Display_Name | CXCR4 Peptide Antagonist LY2510924
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| Preferred_Name | CXCR4 Peptide Antagonist LY2510924
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| Contributing_Source | CTRP
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| Maps_To | CXCR4 Peptide Antagonist LY2510924
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| NCI_Drug_Dictionary_ID | 703819
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 703819
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3827103
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