Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C106118
http://purl.obolibrary.org/obo/NCIT_C106118
Preferred Name

Xentuzumab
Definitions
A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic activity. Upon administration, xentuzumab binds to both IGF-1 and IGF-2 and inhibits the binding of these ligands to their receptor, IGF-1R. This blocks the insulin growth factor (IGF) signaling pathway, which is upregulated in a number of cancer cell types and plays a key role in cancer cell proliferation and chemoresistance. In addition, BI 836845 prevents the binding of IGF-2 to insulin receptor variant A (IR-A), preventing its activation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic activity. Upon administration, xentuzumab binds to both IGF-1 and IGF-2 and inhibits the binding of these ligands to their receptor, IGF-1R. This blocks the insulin growth factor (IGF) signaling pathway, which is upregulated in a number of cancer cell types and plays a key role in cancer cell proliferation and chemoresistance. In addition, BI 836845 prevents the binding of IGF-2 to insulin receptor variant A (IR-A), preventing its activation.
prefLabel
Xentuzumab
label
Xentuzumab
PDQ_Closed_Trial_Search_ID
697680
code
C106118
Has_Target
prefixIRI
NCIT:C106118
in_subset
Display_Name
Xentuzumab
Preferred_Name
Xentuzumab
FDA_UNII_Code
X86Z1O656G
Contributing_Source
CTRP
FDA
Maps_To
Xentuzumab
CAS_Registry
1417158-65-6
NCI_Drug_Dictionary_ID
697680
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
697680
Semantic_Type
Pharmacologic Substance
Immunologic Factor
UMLS_CUI
C3827152
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