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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C105805
http://purl.obolibrary.org/obo/NCIT_C105805
|
|---|---|
| Preferred Name | Anti-CD19 Monoclonal Antibody DI-B4 |
| Definitions |
A low-fucosylated, humanized, IgG1 isotype, monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody DI-B4 binds to CD19, which may result in a strong antibody-dependent cellular cytotoxicity (ADCC) directed at CD19-expressing B-cells but with minimal complement dependent cytotoxicity. DI-B4 contains low levels of fucose, which contributes to its enhanced ADCC activity. CD19 is a B-cell specific membrane antigen that is widely expressed during B-cell development and in all B-cell lineage malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A low-fucosylated, humanized, IgG1 isotype, monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody DI-B4 binds to CD19, which may result in a strong antibody-dependent cellular cytotoxicity (ADCC) directed at CD19-expressing B-cells but with minimal complement dependent cytotoxicity. DI-B4 contains low levels of fucose, which contributes to its enhanced ADCC activity. CD19 is a B-cell specific membrane antigen that is widely expressed during B-cell development and in all B-cell lineage malignancies. |
|---|---|
| prefLabel | Anti-CD19 Monoclonal Antibody DI-B4
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| label | Anti-CD19 Monoclonal Antibody DI-B4
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| NCI_META_CUI | CL447157
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| PDQ_Closed_Trial_Search_ID | 747738
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| code | C105805
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| prefixIRI | NCIT:C105805
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| in_subset | |
| Preferred_Name | Anti-CD19 Monoclonal Antibody DI-B4
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| Maps_To | Anti-CD19 Monoclonal Antibody DI-B4
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| NCI_Drug_Dictionary_ID | 747738
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 747738
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| Semantic_Type | Pharmacologic Substance
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