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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C105802
http://purl.obolibrary.org/obo/NCIT_C105802
|
|---|---|
| Preferred Name | Liposome-encapsulated miR-34 Mimic MRX34 |
| Definitions |
A liposomal formulation containing a nucleotide that mimics the human tumor suppressor microRNA (miRNA) miR-34, with potential antineoplastic activity. Upon administration, liposome-encapsulated MRX34 mimics miR-34 by inhibiting the expression of a variety of oncogenes including MYC, MET, BCL2, and beta-catenin. This induces cell cycle arrest, senescence and apoptosis in susceptible tumor cells. miR-34 is downregulated in most solid and hematologic malignancies and regulates the expression of a variety of genes. This miRNA plays an important role in the inhibition of cancer cell stemness, metastasis and cancer cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A liposomal formulation containing a nucleotide that mimics the human tumor suppressor microRNA (miRNA) miR-34, with potential antineoplastic activity. Upon administration, liposome-encapsulated MRX34 mimics miR-34 by inhibiting the expression of a variety of oncogenes including MYC, MET, BCL2, and beta-catenin. This induces cell cycle arrest, senescence and apoptosis in susceptible tumor cells. miR-34 is downregulated in most solid and hematologic malignancies and regulates the expression of a variety of genes. This miRNA plays an important role in the inhibition of cancer cell stemness, metastasis and cancer cell survival. |
|---|---|
| prefLabel | Liposome-encapsulated miR-34 Mimic MRX34
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| label | Liposome-encapsulated miR-34 Mimic MRX34
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| NCI_META_CUI | CL447293
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| PDQ_Closed_Trial_Search_ID | 747643
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| code | C105802
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| prefixIRI | NCIT:C105802
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| in_subset | |
| Display_Name | Liposome-encapsulated miR-34 Mimic MRX34
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| Preferred_Name | Liposome-encapsulated miR-34 Mimic MRX34
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| Contributing_Source | CTRP
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| Maps_To | Liposome-encapsulated miR-34 Mimic MRX34
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| NCI_Drug_Dictionary_ID | 747643
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 747643
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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