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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1055
http://purl.obolibrary.org/obo/NCIT_C1055
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|---|---|
| Preferred Name | Custirsen Sodium |
| Definitions |
The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance. |
|---|---|
| prefLabel | Custirsen Sodium
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| label | Custirsen Sodium
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| PDQ_Closed_Trial_Search_ID | 271195
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| code | C1055
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| Has_Target | |
| prefixIRI | NCIT:C1055
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| in_subset |
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| Display_Name | Custirsen Sodium
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| Preferred_Name | Custirsen Sodium
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| FDA_UNII_Code | ILE26V76EB
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C231H292N78O119P20S20.20Na
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| Maps_To | Custirsen Sodium
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| CAS_Registry | 685922-56-9
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| NCI_Drug_Dictionary_ID | 271195
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| Legacy Concept Name | OGX-011
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks the production of a protein called clusterin, which helps cells live longer. This may kill cancer cells that need clusterin to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 271195
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C1328699
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