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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C105403
http://purl.obolibrary.org/obo/NCIT_C105403
|
|---|---|
| Preferred Name | Lutetium Lu 177 DOTA-Tetulomab |
| Definitions |
A radioimmunoconjugate, which consists of a monoclonal antibody against the cell-surface antigen CD37 covalently linked, via the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. The antibody moiety of lutetium Lu 177 DOTA-tetulomab binds to CD37 on tumor B-cells. Upon internalization, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate, which consists of a monoclonal antibody against the cell-surface antigen CD37 covalently linked, via the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. The antibody moiety of lutetium Lu 177 DOTA-tetulomab binds to CD37 on tumor B-cells. Upon internalization, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies. |
|---|---|
| prefLabel | Lutetium Lu 177 DOTA-Tetulomab
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| label | Lutetium Lu 177 DOTA-Tetulomab
|
| PDQ_Closed_Trial_Search_ID | 746917
|
| code | C105403
|
| Has_Target | |
| prefixIRI | NCIT:C105403
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| in_subset |
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| Display_Name | Lutetium Lu 177 DOTA-Tetulomab
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| Preferred_Name | Lutetium Lu 177 DOTA-Tetulomab
|
| FDA_UNII_Code | CPW7BR9UY7
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Lutetium Lu 177 DOTA-Tetulomab
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| NCI_Drug_Dictionary_ID | 746917
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 746917
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3659253
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