Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1054
http://purl.obolibrary.org/obo/NCIT_C1054
|
|---|---|
| Preferred Name | Clarithromycin |
| Definitions |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04) |
|---|---|
| prefLabel | Clarithromycin
|
| label | Clarithromycin
|
| CHEBI_ID | CHEBI:3732
|
| PDQ_Closed_Trial_Search_ID | 42308
|
| code | C1054
|
| prefixIRI | NCIT:C1054
|
| in_subset |
See more
See less
|
| Display_Name | Clarithromycin
|
| Preferred_Name | Clarithromycin
|
| FDA_UNII_Code | H1250JIK0A
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C38H69NO13
|
| Maps_To | Clarithromycin
|
| CAS_Registry | 81103-11-9
|
| NSC Number | 643733
|
| NCI_Drug_Dictionary_ID | 42308
|
| Legacy Concept Name | Clarithromycin
|
| type | |
| ALT_DEFINITION | An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42308
|
| Accepted_Therapeutic_Use_For | H. pylori infection; Various bacterial infections
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
|
| UMLS_CUI | C0055856
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |