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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C104746
http://purl.obolibrary.org/obo/NCIT_C104746
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|---|---|
| Preferred Name | IGF-1R Inhibitor PL225B |
| Definitions |
An orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor PL225B selectively binds to and inhibits the activities of IGF-1R, which may result in both the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis in IGF-1R-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor PL225B selectively binds to and inhibits the activities of IGF-1R, which may result in both the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis in IGF-1R-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis. |
|---|---|
| prefLabel | IGF-1R Inhibitor PL225B
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| label | IGF-1R Inhibitor PL225B
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| NCI_META_CUI | CL445817
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| PDQ_Closed_Trial_Search_ID | 746194
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| code | C104746
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| Has_Target | |
| prefixIRI | NCIT:C104746
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| in_subset |
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| Display_Name | IGF-1R Inhibitor PL225B
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| Preferred_Name | IGF-1R Inhibitor PL225B
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| Contributing_Source | CTRP
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| Maps_To | IGF-1R Inhibitor PL225B
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| NCI_Drug_Dictionary_ID | 746194
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 746194
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| Semantic_Type | Pharmacologic Substance
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