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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C104260
http://purl.obolibrary.org/obo/NCIT_C104260
|
|---|---|
| Preferred Name | Imalumab |
| Definitions |
A human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine overexpressed in some cancers, plays a key role in inflammation, immune responses and cancer cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine overexpressed in some cancers, plays a key role in inflammation, immune responses and cancer cell proliferation. |
|---|---|
| prefLabel | Imalumab
|
| label | Imalumab
|
| NCI_META_CUI | CL446652
|
| PDQ_Closed_Trial_Search_ID | 740468
|
| code | C104260
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| Has_Target | |
| prefixIRI | NCIT:C104260
|
| in_subset |
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| Display_Name | Imalumab
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| Preferred_Name | Imalumab
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| FDA_UNII_Code | 22F97PC79G
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Imalumab
|
| CAS_Registry | 1430205-07-4
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| NCI_Drug_Dictionary_ID | 740468
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 740468
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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