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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C104045
http://purl.obolibrary.org/obo/NCIT_C104045
|
|---|---|
| Preferred Name | ERK Inhibitor MK-8353 |
| Definitions |
An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, MK-8353 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways; thereby, preventing ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a role in tumor cell proliferation, differentiation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, MK-8353 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways; thereby, preventing ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a role in tumor cell proliferation, differentiation and survival. |
|---|---|
| prefLabel | ERK Inhibitor MK-8353
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| label | ERK Inhibitor MK-8353
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| NCI_META_CUI | CL433840
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| PDQ_Closed_Trial_Search_ID | 701114
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| code | C104045
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| Has_Target | |
| prefixIRI | NCIT:C104045
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| in_subset | |
| Display_Name | ERK Inhibitor MK-8353
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| Preferred_Name | ERK Inhibitor MK-8353
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| Contributing_Source | CTRP
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| Maps_To | ERK Inhibitor MK-8353
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| NCI_Drug_Dictionary_ID | 701114
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 701114
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| Semantic_Type | Pharmacologic Substance
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