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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C103274
http://purl.obolibrary.org/obo/NCIT_C103274
|
|---|---|
| Preferred Name | Brontictuzumab |
| Definitions |
A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation. Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as a receptor for membrane bound ligands and has various roles during development; dysregulated Notch signaling is associated with increased cell growth and chemoresistance in cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation. Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as a receptor for membrane bound ligands and has various roles during development; dysregulated Notch signaling is associated with increased cell growth and chemoresistance in cancers. |
|---|---|
| prefLabel | Brontictuzumab
|
| label | Brontictuzumab
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| NCI_META_CUI | CL438125
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| PDQ_Closed_Trial_Search_ID | 741867
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| code | C103274
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| Has_Target | |
| prefixIRI | NCIT:C103274
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| in_subset |
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| Display_Name | Brontictuzumab
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| Preferred_Name | Brontictuzumab
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| FDA_UNII_Code | UNY2TQA40E
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Brontictuzumab
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| CAS_Registry | 1447814-75-6
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| NCI_Drug_Dictionary_ID | 741867
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 741867
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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