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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C103273
http://purl.obolibrary.org/obo/NCIT_C103273
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|---|---|
| Preferred Name | Erdafitinib |
| Definitions |
An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, erdafitinib binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, erdafitinib binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival. |
|---|---|
| label | Erdafitinib
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| prefLabel | Erdafitinib
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| in_subset |
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| Preferred_Name | Erdafitinib
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| Is_Value_For_GDC_Property | |
| Display_Name | Erdafitinib
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| Maps_To | Erdafitinib
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| PDQ_Open_Trial_Search_ID | 741845
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| Has_Target | |
| UMLS_CUI | C3641169
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| FDA_UNII_Code | 890E37NHMV
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| prefixIRI | NCIT:C103273
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| Accepted_Therapeutic_Use_For | locally advanced or metastatic urothelial carcinoma
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| NCI_Drug_Dictionary_ID | 741845
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C103273
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| type | |
| PDQ_Closed_Trial_Search_ID | 741845
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 1346242-81-6
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