Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1031 http://purl.obolibrary.org/obo/NCIT_C1031
Preferred Name	Piritrexim
Definitions	A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04)
prefLabel	Piritrexim
label	Piritrexim
Has_Salt_Form	http://purl.obolibrary.org/obo/NCIT_C91407
PDQ_Closed_Trial_Search_ID	40070
code	C1031
prefixIRI	NCIT:C1031
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Piritrexim
FDA_UNII_Code	MK2A783ZUT
Contributing_Source	FDA
Chemical_Formula	C17H19N5O2
Maps_To	Piritrexim
CAS_Registry	72732-56-0
NSC Number	351521
NCI_Drug_Dictionary_ID	40070
Legacy Concept Name	Piritrexim
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called folate antagonists.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C511 http://purl.obolibrary.org/obo/NCIT_C2153
PDQ_Open_Trial_Search_ID	40070
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0054332

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