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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C102878
http://purl.obolibrary.org/obo/NCIT_C102878
|
|---|---|
| Preferred Name | Boanmycin Hydrochloride |
| Definitions |
The hydrochloride salt form of boanmycin (aka bleomycin A6), a component of the antibiotic bleomycin produced by Streptomyces species, with potential antineoplastic activity. Upon administration, boanmycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This causes single- and double-stranded DNA breaks which eventually leads to cell death. Compared to bleomycin, boanmycin appears to have a more favorable toxicity profile.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of boanmycin (aka bleomycin A6), a component of the antibiotic bleomycin produced by Streptomyces species, with potential antineoplastic activity. Upon administration, boanmycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This causes single- and double-stranded DNA breaks which eventually leads to cell death. Compared to bleomycin, boanmycin appears to have a more favorable toxicity profile. |
|---|---|
| prefLabel | Boanmycin Hydrochloride
|
| label | Boanmycin Hydrochloride
|
| NCI_META_CUI | CL437181
|
| PDQ_Closed_Trial_Search_ID | 738501
|
| code | C102878
|
| prefixIRI | NCIT:C102878
|
| in_subset | |
| Preferred_Name | Boanmycin Hydrochloride
|
| Maps_To | Boanmycin Hydrochloride
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| NCI_Drug_Dictionary_ID | 738501
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 738501
|
| Semantic_Type | Antibiotic
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