Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1026
http://purl.obolibrary.org/obo/NCIT_C1026
Preferred Name

Bryostatin 1
Definitions
A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)
prefLabel
Bryostatin 1
label
Bryostatin 1
PDQ_Closed_Trial_Search_ID
41959
code
C1026
Has_Target
prefixIRI
NCIT:C1026
in_subset
Display_Name
Bryostatin 1
Preferred_Name
Bryostatin 1
FDA_UNII_Code
37O2X55Y9E
Contributing_Source
CTRP
FDA
Chemical_Formula
C47H68O17
Maps_To
Bryostatin 1
CAS_Registry
83314-01-6
NSC Number
339555
NCI_Drug_Dictionary_ID
41959
Legacy Concept Name
Bryostatin-1
type
ALT_DEFINITION
A substance being studied in the treatment of cancer and certain brain conditions such as Alzheimer disease and stroke. It binds to an enzyme involved in cell growth and it may help anticancer drugs work better. Bryostatin 1 comes from a marine organism. It is a type of protein kinase C modulator.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41959
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0054173
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display