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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1019
http://purl.obolibrary.org/obo/NCIT_C1019
|
|---|---|
| Preferred Name | Bisantrene |
| Definitions |
An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04) |
|---|---|
| prefLabel | Bisantrene
|
| label | Bisantrene
|
| Has_Salt_Form | |
| code | C1019
|
| prefixIRI | NCIT:C1019
|
| in_subset | |
| Preferred_Name | Bisantrene
|
| FDA_UNII_Code | 39C34M111K
|
| Contributing_Source | FDA
|
| Chemical_Formula | C22H22N8
|
| Maps_To | Bisantrene
|
| CAS_Registry | 78186-34-2
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| NSC Number | 337766
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| Legacy Concept Name | Bisantrene
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0053776
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