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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C101795
http://purl.obolibrary.org/obo/NCIT_C101795
|
|---|---|
| Preferred Name | TORC1/2 Kinase Inhibitor DS-3078a |
| Definitions |
An orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR protein complex (TORC2) with potential antineoplastic activity. TORC1/2 inhibitor DS-3078a binds to and inhibits both TORC1 and TORC2, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR protein complex (TORC2) with potential antineoplastic activity. TORC1/2 inhibitor DS-3078a binds to and inhibits both TORC1 and TORC2, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. |
|---|---|
| prefLabel | TORC1/2 Kinase Inhibitor DS-3078a
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| label | TORC1/2 Kinase Inhibitor DS-3078a
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| NCI_META_CUI | CL435913
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| PDQ_Closed_Trial_Search_ID | 733685
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| code | C101795
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| prefixIRI | NCIT:C101795
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| in_subset | |
| Preferred_Name | TORC1/2 Kinase Inhibitor DS-3078a
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| Maps_To | TORC1/2 Kinase Inhibitor DS-3078a
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| NCI_Drug_Dictionary_ID | 733685
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 733685
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| Semantic_Type | Pharmacologic Substance
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