Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C101523
http://purl.obolibrary.org/obo/NCIT_C101523
|
|---|---|
| Preferred Name | Hypoxia-activated Prodrug TH-4000 |
| Definitions |
A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. |
|---|---|
| prefLabel | Hypoxia-activated Prodrug TH-4000
|
| label | Hypoxia-activated Prodrug TH-4000
|
| NCI_META_CUI | CL435780
|
| PDQ_Closed_Trial_Search_ID | 732241
|
| code | C101523
|
| prefixIRI | NCIT:C101523
|
| in_subset |
See more
See less
|
| Display_Name | Hypoxia-activated Prodrug TH-4000
|
| Preferred_Name | Hypoxia-activated Prodrug TH-4000
|
| Contributing_Source | CTRP
|
| Maps_To | Hypoxia-activated Prodrug TH-4000
|
| NCI_Drug_Dictionary_ID | 732241
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 732241
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |