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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C101368
http://purl.obolibrary.org/obo/NCIT_C101368
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|---|---|
| Preferred Name | Danvatirsen |
| Definitions |
An antisense oligonucleotide targeting signal transducer and activator of transcription 3 (STAT3) with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth. STAT3, a protein overexpressed in a variety of human cancers, plays a critical role in tumor cell growth and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antisense oligonucleotide targeting signal transducer and activator of transcription 3 (STAT3) with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth. STAT3, a protein overexpressed in a variety of human cancers, plays a critical role in tumor cell growth and survival. |
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| prefLabel | Danvatirsen
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| label | Danvatirsen
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| NCI_META_CUI | CL435548
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| PDQ_Closed_Trial_Search_ID | 729992
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| code | C101368
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| prefixIRI | NCIT:C101368
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| in_subset |
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| Display_Name | Danvatirsen
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| Preferred_Name | Danvatirsen
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| FDA_UNII_Code | 31N550RD05
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Danvatirsen
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| CAS_Registry | 1402357-06-5
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| NCI_Drug_Dictionary_ID | 729992
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 729992
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| Semantic_Type | Pharmacologic Substance
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