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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1011
http://purl.obolibrary.org/obo/NCIT_C1011
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|---|---|
| Preferred Name | Beauvericin |
| Definitions |
A cyclic hexadepsipeptide antibiotic and mycotoxin isolated from the fungus Beauveria bassiana and various Fusarium fungal species. As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway. This agent has been studied as a potential antineoplastic agent. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cyclic hexadepsipeptide antibiotic and mycotoxin isolated from the fungus Beauveria bassiana and various Fusarium fungal species. As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway. This agent has been studied as a potential antineoplastic agent. (NCI04) |
|---|---|
| label | Beauvericin
|
| prefLabel | Beauvericin
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| Legacy Concept Name | Beauvericin
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| in_subset | |
| Preferred_Name | Beauvericin
|
| Is_Value_For_GDC_Property | |
| Maps_To | Beauvericin
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| UMLS_CUI | C0053065
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| FDA_UNII_Code | 26S048LS2R
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| prefixIRI | NCIT:C1011
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| Contributing_Source | FDA
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| subClassOf | |
| CHEBI_ID | CHEBI:3000
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| code | C1011
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| type | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
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| CAS_Registry | 26048-05-5
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