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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1008
http://purl.obolibrary.org/obo/NCIT_C1008
|
|---|---|
| Preferred Name | Azaribine |
| Definitions |
The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis. |
|---|---|
| prefLabel | Azaribine
|
| label | Azaribine
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| PDQ_Closed_Trial_Search_ID | 39155
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| code | C1008
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| prefixIRI | NCIT:C1008
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| in_subset | |
| Preferred_Name | Azaribine
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| FDA_UNII_Code | K1U80DO9EB
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| Contributing_Source | FDA
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| Chemical_Formula | C14H17N3O9
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| Maps_To | Azaribine
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| CAS_Registry | 2169-64-4
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| NSC Number | 67239
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| NCI_Drug_Dictionary_ID | 39155
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| Legacy Concept Name | Azauridine_Triacetate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39155
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0052757
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| Delete | Subject | Author | Type | Created |
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