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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/GO_0031594
http://purl.obolibrary.org/obo/GO_0031594
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|---|---|
| Preferred Name | neuromuscular junction |
| Definitions |
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
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| Synonyms |
motor endplate
NMJ
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
|---|---|
| label |
neuromuscular junction
|
| comment |
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
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| prefLabel |
neuromuscular junction
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| database_cross_reference |
Wikipedia:Neuromuscular_junction
NIF_Subcellular:sao1124888485
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| notation |
GO:0031594
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| has_related_synonym |
motor endplate
NMJ
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| id |
GO:0031594
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| has_obo_namespace |
cellular_component
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| subClassOf | |
| overlaps | |
| type | |
| alternative term |
motor endplate
NMJ
|
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