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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | lomustine | |
| Synonyms |
1-(2-chloroethyl)-3-cyclohexylnitrosourea cyclohexyl chloroethyl nitrosourea N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea chloroethylcyclohexylnitrosourea 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea Belustine CCNU CINU Cecenu CeeNU lomustina lomustine lomustinum 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea |
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| Definitions |
An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_6520 |
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| alternative term |
1-(2-chloroethyl)-3-cyclohexylnitrosourea cyclohexyl chloroethyl nitrosourea N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea chloroethylcyclohexylnitrosourea 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea Belustine CCNU CINU Cecenu CeeNU lomustina lomustine lomustinum 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
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| bearer of | ||
| charge |
0
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| database_cross_reference |
PMID:24368412 PMID:19901016 Reaxys:2125058 PMID:22577051 KEGG:C07079 PMID:12153595 PMID:20719460 Drug_Central:1596 PMID:24293673 DrugBank:DB01206 CAS:13010-47-4 Wikipedia:Lomustine HMDB:HMDB0015337 PMID:24516018 KEGG:D00363 PMID:6762924
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|
| definition |
An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.
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|
| formula |
C9H16ClN3O2
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|
| has_exact_synonym |
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
1-(2-chloroethyl)-3-cyclohexylnitrosourea cyclohexyl chloroethyl nitrosourea N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea chloroethylcyclohexylnitrosourea 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea Belustine CCNU CINU Cecenu CeeNU lomustina lomustine lomustinum
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|
| id |
CHEBI:6520
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| in_subset | ||
| inchi |
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
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| inchikey |
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
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|
| label |
lomustine
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|
| mass |
233.69500
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|
| monoisotopicmass |
233.09310
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| notation |
CHEBI:6520
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| prefLabel |
lomustine
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| RO_0000087 | ||
| smiles |
ClCCN(N=O)C(=O)NC1CCCCC1
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| subClassOf |
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