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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/CHEBI_64354
http://purl.obolibrary.org/obo/CHEBI_64354
|
|---|---|
| Preferred Name | metolazone |
| Definitions |
A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
|
| Synonyms |
metolazonum
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
Zaroxolyn
metolazona
metolazone
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. |
|---|---|
| label |
metolazone
|
| prefLabel |
metolazone
|
| database_cross_reference |
PMID:12671341
PMID:8870895
Wikipedia:Metolazone
PMID:15095363
PMID:8205244
PMID:16717105
PMID:1593359
PMID:16538931
PMID:21387350
PMID:1886511
PMID:2071258
PMID:1928234
PMID:1946137
CAS:17560-51-9
Patent:US3360518
PMID:16189620
DrugBank:DB00524
Patent:US2008139593
PMID:9089428
LINCS:LSM-1680
Drug_Central:1783
PMID:21886902
PMID:16908225
PMID:8199745
KEGG:D00431
Reaxys:965506
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|
| notation |
CHEBI:64354
|
| in_subset | |
| inchi |
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
|
| has_related_synonym |
metolazonum
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
Zaroxolyn
metolazona
metolazone
See more
See less
|
| id |
CHEBI:64354
|
| charge |
0
|
| has_obo_namespace |
chebi_ontology
|
| formula |
C16H16ClN3O3S
|
| subClassOf | |
| inchikey |
AQCHWTWZEMGIFD-UHFFFAOYSA-N
|
| mass |
365.83500
|
| monoisotopicmass |
365.06009
|
| has_alternative_id |
CHEBI:6903
|
| type | |
| smiles |
CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O
|
| RO_0000087 | |
| has_exact_synonym |
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
|
| bearer of | |
| alternative term |
metolazonum
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
Zaroxolyn
metolazona
metolazone
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
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|
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