Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/CHEBI_5102 http://purl.obolibrary.org/obo/CHEBI_5102
Preferred Name	fludrocortisone acetate
Definitions	An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
Synonyms	(11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Alflorone acetate 9alpha-fluorohydrocortisone 21-acetate F-Cortef acetate 9alpha-fluorohydrocortisone acetate Florinef acetate fluohydrocortisone acetate fludrocortisone 21-acetate Scherofluron fluorocortisone acetate Alflorone Cortef-F Cortineff F-Cortef Florinef U 4845 9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
label	fludrocortisone acetate
prefLabel	fludrocortisone acetate
database_cross_reference	Patent:US2957013 PMID:13361498 PMID:438959 Reaxys:3019450 PMID:24316163 PMID:8164382 PMID:13271122 PMID:8248344 KEGG:C08186 KEGG:D00986 Drug_Central:1191 PMID:18193551 CAS:514-36-3 PMID:3197346 See more See less
notation	CHEBI:5102
in_subset	http://purl.obolibrary.org/obo/chebi#3_STAR
inchi	InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
has_related_synonym	(11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Alflorone acetate 9alpha-fluorohydrocortisone 21-acetate F-Cortef acetate 9alpha-fluorohydrocortisone acetate Florinef acetate fluohydrocortisone acetate fludrocortisone 21-acetate Scherofluron fluorocortisone acetate Alflorone Cortef-F Cortineff F-Cortef Florinef U 4845 See more See less
id	CHEBI:5102
charge	0
has_obo_namespace	chebi_ontology
formula	C23H31FO6
subClassOf	http://purl.obolibrary.org/obo/CHEBI_47622 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_25354 http://purl.obolibrary.org/obo/CHEBI_50830 http://purl.obolibrary.org/obo/CHEBI_35342 http://purl.obolibrary.org/obo/CHEBI_47909 http://purl.obolibrary.org/obo/CHEBI_35346 See more See less
inchikey	SYWHXTATXSMDSB-GSLJADNHSA-N
mass	422.48700
monoisotopicmass	422.21047
has_functional_parent	http://purl.obolibrary.org/obo/CHEBI_50885
type	http://www.w3.org/2002/07/owl#Class
smiles	CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
has_exact_synonym	9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
alternative term	(11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Alflorone acetate 9alpha-fluorohydrocortisone 21-acetate F-Cortef acetate 9alpha-fluorohydrocortisone acetate Florinef acetate fluohydrocortisone acetate fludrocortisone 21-acetate Scherofluron fluorocortisone acetate Alflorone Cortef-F Cortineff F-Cortef Florinef U 4845 9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate See more See less

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