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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/CHEBI_3011
http://purl.obolibrary.org/obo/CHEBI_3011
|
|---|---|
| Preferred Name | benazepril |
| Definitions |
A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
|
| Synonyms |
benazeprilum
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
benazepril
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
Benazepril
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. |
|---|---|
| label |
benazepril
|
| prefLabel |
benazepril
|
| database_cross_reference |
KEGG:D07499
Drug_Central:299
PMID:25738503
HMDB:HMDB0014682
CAS:86541-75-5
Reaxys:4302258
PMID:25784709
Patent:US4410520
Patent:EP72352
LINCS:LSM-5609
PMID:25224804
MetaCyc:CPD-15329
DrugBank:DB00542
Wikipedia:Benazepril
PMID:25912588
KEGG:C06843
See more
See less
|
| notation |
CHEBI:3011
|
| in_subset | |
| inchi |
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
|
| has_related_synonym |
benazeprilum
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
benazepril
|
| id |
CHEBI:3011
|
| charge |
0
|
| has_obo_namespace |
chebi_ontology
|
| formula |
C24H28N2O5
|
| subClassOf | |
| is_conjugate_base_of | |
| inchikey |
XPCFTKFZXHTYIP-PMACEKPBSA-N
|
| mass |
424.48950
|
| monoisotopicmass |
424.19982
|
| has_functional_parent | |
| type | |
| smiles |
CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O
|
| RO_0000087 | |
| has_exact_synonym |
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
Benazepril
|
| bearer of | |
| alternative term |
benazeprilum
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
benazepril
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
Benazepril
|
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