loading...| Preferred Name |
esophagus |
|
| Synonyms |
oesophagus gullet |
|
| Definitions |
Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). |
|
| ID |
http://purl.obolibrary.org/obo/UBERON_0001043 |
|
| database_cross_reference |
http://linkedlifedata.com/resource/umls/id/C0014876 http://www.snomedbrowser.com/Codes/Details/181245004 http://en.wikipedia.org/wiki/Esophagus TAO:0000204 MAT:0000048 EFO:0000835 AAO:0000145 EMAPA:16833 VHOG:0000450 UMLS:C0014876 OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA MA:0000352 EHDAA2:0001285 EHDAA:2937 galen:Esophagus NCIT:C12389 FMA:7131 ANISEED:1235301 BTO:0000959 GAID:291 CALOHA:TS-0700 XAO:0000127 MESH:A03.365 EV:0100069 MIAA:0000048 ZFA:0000204 |
|
| depicted by |
http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg |
|
| external_definition |
Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO] |
|
| external_ontology_notes |
esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995) |
|
| has exact synonym |
oesophagus gullet |
|
| has_obo_namespace |
uberon |
|
| has_relational_adjective |
esophageal |
|
| homologous_in | ||
| homology_notes |
The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG] |
|
| id |
UBERON:0001043 |
|
| imported from | ||
| in_subset |
http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#organ_slim http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#organ_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core http://purl.obolibrary.org/obo/uberon/core#major_organ http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ |
|
| label |
esophagus |
|
| notation |
UBERON:0001043 |
|
| prefLabel |
esophagus |
|
| textual definition |
Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). |
|
| subClassOf |
The BioAssay Ontology integrates with OntoloBridge, allowing community users to suggest additions to the public ontology. Complete the template below to submit a term request directly to the ontology maintainer.
Term Label (required)
Suggested term name. If a term can be described with multiple synonyms, only list the preferred name here.
Example: tissue-based format
Term description (required)
A brief definition, description, or usage of your suggested term. Additional term synonyms may be listed in this section.
Example: Involves the use of a tissue derived from a living organism and is a heterogeneous assay type.
Superclass (required)
The parent term of the suggested term. The parent term should be an existing entry of the current ontology. The superclass can be selected directly from the 'Classes' viewer on Bioportal's left tree navigation.
Example: assay format
References (optional)
Provide evidence for the existence of the requested term such as PMIDs of papers or links to other resources that describe the term.
Justification (optional)
Provide any additional information about the requested term here.