loading...| Preferred Name | Transforming growth factor beta | |
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| ID |
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596097 |
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| altLabel |
TGF-b TGF-β TGFbeta |
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| definition |
TGF-β has an anti-inflammatory effect by inhibiting excessive neuroinflammation during the subacute phase of brain ischemia. A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. |
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| label |
Transforming growth factor beta |
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| prefLabel |
Transforming growth factor beta |
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| references |
Shichita, T., Ito, M., & Yoshimura, A. (2014). Post-ischemic inflammation regulates neural damage and protection. Frontiers in cellular neuroscience, 8. |
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| subClassOf |
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596047 http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571345044435365941 |