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| ID: | PRO:000000669 |
| Full Id: | PRO:000000669 |
| Synonyms: | "CatSper1" |
| Definitions: | A protein that is a translation product of the CATSPER1 gene. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PRO:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N-terminus that seems to be involved the pH sensitivity of the channel calcium currents. |
| Comment: | Category=gene. |
| Exact Synonym: | "CatSper1" |
| Is A: | protein |
| Sub Class: | cation channel sperm-associated protein 1 isoform 1 |
| Mapping To | Source | Mapped By | Mapped On | Notes |
|---|---|---|---|---|
| CatSper1 (NIFSTD) | LOOM | amirg | 08/13/09 | View Notes |
: Relationship is "IS_A"
: Relationship is "PART_OF"







