Sickle Cell Disease Ontology

Last uploaded: December 15, 2018
Preferred Name

Metronidazole

Definitions

'A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. [Curator team: SCD Management guidelines - Tanzania []]'

ID

http://scdontology.h3abionet.org/ontology/SCDO_0002912

curator note

Used for the management of cholelithiasis

database cross reference

CHEBI:6909

definition

'A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. [Curator team: SCD Management guidelines - Tanzania []]'

definition source

http://purl.obolibrary.org/obo/CHEBI_6909

prefixIRI

ontology:SCDO_0002912

prefLabel

Metronidazole

rdfs:label

Metronidazole

subClassOf

http://scdontology.h3abionet.org/ontology/SCDO_0000930

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http://purl.bioontology.org/ontology/RXNORM/6922 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372602008 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002300 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Metronidazole GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008795 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002958 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.658.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/A01AB17 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP14997-8 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146194 ODAE LOOM
http://purl.bioontology.org/ontology/UATC/G01AF01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/D06BX01 ATC LOOM
http://purl.bioontology.org/ontology/CSP/1549-4919 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-52040 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146194 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.640.672.500 RH-MESH LOOM
http://purl.jp/bio/4/id/200906013134576937 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039503 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4017836 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/P01AB01 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/1222004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/J01XD01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D008795 MESH LOOM