Preferred Name |
Vindesine |
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Synonyms |
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Definitions |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C934 |
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definition |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
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isDefinedBy | ||
label |
Vindesine |
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prefixIRI |
ncit:C934 |
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prefLabel |
Vindesine |
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seeAlso |
EuroCAT Umbrella Protocol for NSCLC |
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subClassOf |