Radiation Oncology Ontology

Last uploaded: June 19, 2018
Preferred Name

Vinblastine

Synonyms
Definitions

A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C930

definition

A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)

isDefinedBy

http://purl.bioontology.org/ontology/NCIT

label

Vinblastine

prefixIRI

ncit:C930

prefLabel

Vinblastine

seeAlso

EuroCAT Umbrella Protocol for NSCLC

subClassOf

http://purl.bioontology.org/ontology/STY/T121

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C932

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C930 NCIT SAME_URI
http://purl.obolibrary.org/obo/XCO_0000620 XCO LOOM
http://purl.bioontology.org/ontology/ATC/L01CA01 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0015578 OMIT LOOM
http://purl.bioontology.org/ontology/RCD/x01Aj RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/11198 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-78240 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D014747 MESH LOOM
http://purl.obolibrary.org/obo/MESH_D014747 BERO LOOM
http://stirdf.jst.go.jp/id/200907003234346163 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002654 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_27375 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_27375 DRON LOOM
http://purl.obolibrary.org/obo/dinto_DB00570 DINTO LOOM
http://purl.jp/bio/4/id/200906032479335228 IOBC LOOM
https://go.drugbank.com/drugs/DB00570 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12997 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014747 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C930 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.473.402.681.827.650 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00570 FTC LOOM
http://www.co-ode.org/ontologies/galen#Vinblastine GALEN LOOM
http://purl.obolibrary.org/obo/NCIT_C930 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148055 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/0093-3413 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387051009 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017735 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042670 OCHV LOOM
http://www.gamuts.net/entity#vinblastine GAMUTS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.436.681.827.650 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019970 VANDF LOOM