Radiation Oncology Ontology

Last uploaded: June 19, 2018
Preferred Name

Cetuximab

Synonyms
Definitions

A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1723

definition

A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.

isDefinedBy

http://purl.bioontology.org/ontology/NCIT

label

Cetuximab

prefixIRI

ncit:C1723

prefLabel

Cetuximab

seeAlso

EuroCAT Umbrella Protocol for NSCLC

subClassOf

http://purl.bioontology.org/ontology/STY/T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1723 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1723 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/008568 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000068818 MESH LOOM
http://purl.bioontology.org/ontology/npo#NPO_577 NPO LOOM
http://purl.obolibrary.org/obo/NCIT_C1723 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP220476-8 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0001333 OMIT LOOM
http://ontology.lst.tfo.upm.es/BD2D/chemo#Cancer_Therapy_Agent_Name@@2 HENECON LOOM
http://purl.obolibrary.org/obo/DRON_00018764 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00018764 DRON LOOM
http://www.drugbank.ca/drugs/DB00002 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/409400001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/L01FE01 ATC LOOM
http://purl.jp/bio/4/id/200906015776372378 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0995188 OCHV LOOM
https://go.drugbank.com/drugs/DB00002 MDM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022038 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042384 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/318341 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4021419 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148833 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D000068818 BERO LOOM
http://purl.obolibrary.org/obo/dinto_DB00002 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C411189 RH-MESH LOOM
http://ontology.lst.tfo.upm.es/SPT/follow#Cancer_Therapy_Agent_Name_rec_met@@2 HENEGEO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#53884 OCHV LOOM