Radiation Oncology Ontology

Last uploaded: June 19, 2018
Preferred Name

Docetaxel

Definitions

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526

definition

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

isDefinedBy

http://purl.bioontology.org/ontology/NCIT

label

Docetaxel

prefixIRI

ncit:C1526

prefLabel

Docetaxel

seeAlso

EuroCAT Umbrella Protocol for NSCLC

subClassOf

http://purl.bioontology.org/ontology/STY/T121

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1490

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067311 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020968 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/72962 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148441 ODAE LOOM
http://www.co-ode.org/ontologies/galen#Docetaxel GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386918005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041657 PDQ LOOM
http://purl.bioontology.org/ontology/RCD/h5E.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148441 NDFRT LOOM
http://www.ifomis.org/acgt/1.0#Docetaxel ACGT-MO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108806006 SNOMEDCT LOOM
http://d-nb.info/gnd/4501869-8 FAST-TOPICAL LOOM
http://www.drugbank.ca/drugs/DB01248 FTC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/L01CD02 ATC LOOM
http://purl.bioontology.org/ontology/MESH/C067311 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT SAME_URI
http://stirdf.jst.go.jp/id/200907094393798330 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/005187 NDDF LOOM