Radiation Oncology Ontology

Last uploaded: June 19, 2018
Preferred Name

Carboplatin

Definitions

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282

definition

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

isDefinedBy

http://purl.bioontology.org/ontology/NCIT

label

Carboplatin

prefixIRI

ncit:C1282

prefLabel

Carboplatin

seeAlso

EuroCAT Umbrella Protocol for NSCLC

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1450

http://purl.bioontology.org/ontology/STY/T121

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016190 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.691.800.338 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002643 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D016190 MESH LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_31355 NPO LOOM
http://www.ifomis.org/acgt/1.0#Carboplatin ACGT-MO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386905002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/40048 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039176 PDQ LOOM
http://purl.bioontology.org/ontology/CSP/4007-0021 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/L01XA02 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 NCIT SAME_URI
http://purl.bioontology.org/ontology/RCD/h52.. RCD LOOM
http://www.co-ode.org/ontologies/galen#Carboplatin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4019478 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147598 ODAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147598 NDFRT LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM