Protein-ligand interaction ontology

Last uploaded: November 3, 2014
Preferred Name

Affinity

ID

http://www.semanticweb.org/ontologies/2010/3/Ontology1271664172453.owl#Affinity

isDefinedBy

Affinity is the tendency of a molecule to associate with another. The affinity of a drug is its ability to bind to its biological target (receptor, enzyme, transport system, etc.) For pharmacological receptors it can be thought of as the frequency with which the drug, when brought into the proximity of a receptor by diffusion, will reside at a position of minimum free energy within the force field of that receptor. For an agonist (or for an antagonist) the numerical representation of affinity is the reciprocal of the equilibrium dissociation constant of the ligand-receptor complex denoted K A, calculated as the rate constant for offset (k -1) divided by the rate constant for onset (k 1).

prefixIRI

Ontology1271664172453:Affinity

prefLabel

Affinity

Reference

Wermuth, C.G., et al., Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998). Pure Appl. Chem., 1998. 70(5): p. 1129-1143.

Synonym

affinity affinities binding affinity binding affinities receptor ligand affinity bioaffinity

subClassOf

http://www.semanticweb.org/ontologies/2010/3/Ontology1271664172453.owl#binding_activity

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20604 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20604 NCIT LOOM
http://purl.obolibrary.org/obo/PATO_0002070 OBI_BCGO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 MS LOOM
http://purl.obolibrary.org/obo/PATO_0002070 PATO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 UPHENO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 NIFDYS LOOM
http://purl.obolibrary.org/obo/PATO_0002070 ZP LOOM
http://purl.obolibrary.org/obo/PATO_0002070 TXPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 NIFSTD LOOM
http://purl.obolibrary.org/obo/PATO_0002070 CL LOOM
http://purl.obolibrary.org/obo/PATO_0002070 FLOPO LOOM
http://purl.obolibrary.org/obo/PATO_0002070 AFO LOOM
http://www.stanford.edu/~coulet/phare.owl#GeneProductAffinity PHARE LOOM
http://purl.org/obo/owl/PATO#PATO_0002070 HUPSON LOOM
http://purl.org/obo/owl/PATO#PATO_0002070 BIOMODELS LOOM
http://www.cea.fr/ontotoxnuc#Affinite ONTOTOXNUC LOOM
http://www.semanticweb.org/com/ontologies/2015/4/untitled-ontology-44#AFFINITY PCMO LOOM
http://purl.jp/bio/4/id/200906093640612678 IOBC LOOM