loading...| Preferred Name |
voriconazole |
|
| Synonyms |
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol voriconazole voriconazolum (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol voriconazol (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol VCZ Vfend |
|
| Definitions |
A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_10023 |
|
| charge |
0 |
|
| database_cross_reference |
Patent:EP440372 LINCS:LSM-5244 Drug_Central:2846 PMID:22718362 DrugBank:DB00582 KEGG:D00578 PMID:24102553 CAS:137234-62-9 Wikipedia:Voriconazole PMID:23392902 PMID:23527908 PMID:23766489 Beilstein:7694998 Patent:US5278175 PMID:12940129 KEGG:C07622 |
|
| formula |
C16H14F3N5O |
|
| has role | ||
| has_alternative_id |
CHEBI:127308 |
|
| has_exact_synonym |
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol voriconazole |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
voriconazolum (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol voriconazol voriconazole (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol VCZ Vfend |
|
| id |
CHEBI:10023 |
|
| in_subset | ||
| inchi |
InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
|
| inchikey |
BCEHBSKCWLPMDN-MGPLVRAMSA-N |
|
| label |
voriconazole |
|
| mass |
349.31050 |
|
| monoisotopicmass |
349.11504 |
|
| notation |
CHEBI:10023 |
|
| prefLabel |
voriconazole |
|
| smiles |
C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |
|
| textual definition |
A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_38582 http://purl.obolibrary.org/obo/CHEBI_87101 http://purl.obolibrary.org/obo/CHEBI_26878 |