Preferred Name |
granisetron |
|
Synonyms |
Sancuso |
|
Definitions |
An indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62031" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62031" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000794007 |
|
altLabel |
Sancuso 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide Sustol |
|
CAS Registry |
109889-09-0 |
|
cui |
C0061863 C2370075 C4283667 |
|
DATE FIRST PUBLISHED |
2018-07-12 |
|
Date last modified |
2018-07-17 |
|
definition |
An indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62031" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62031" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C62031 |
|
notation |
CDR0000794007 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
granisetron |
|
tui |
T109 T121 |