loading...| Preferred Name |
liraglutide |
|
| Synonyms |
N26-(hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide |
|
| Definitions |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82239" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82239" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000792738 |
|
| altLabel |
N26-(hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide Victoza NN2211 |
|
| CAS Registry |
204656-20-2 |
|
| cui |
C1456408 C1099192 C2732208 |
|
| DATE FIRST PUBLISHED |
2018-03-27 |
|
| Date last modified |
2018-05-01 |
|
| definition |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82239" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82239" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C82239 |
|
| notation |
CDR0000792738 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
liraglutide |
|
| tui |
T125 T116 T121 |