loading...| Preferred Name |
aztreonam |
|
| Synonyms |
SQ 26,776 |
|
| Definitions |
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28845" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000788184 |
|
| altLabel |
SQ 26,776 Azactam |
|
| CAS Registry |
78110-38-0 |
|
| cui |
C0004521 C0728974 C0699281 |
|
| DATE FIRST PUBLISHED |
2017-04-05 |
|
| Date last modified |
2017-04-05 |
|
| definition |
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28845" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28845 |
|
| notation |
CDR0000788184 |
|
| NSC Code |
646279 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aztreonam |
|
| tui |
T109 T195 |