loading...| Preferred Name |
melphalan |
|
| Synonyms |
L-PAM |
|
| Definitions |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C633" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C633" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000779085 |
|
| altLabel |
L-PAM phenylalanine nitrogen mustard Sarkolysin L-sarcolysin L-phenylalanine mustard Melphalanum CB-3025 Alkeran 4-[bis(2-chloroethyl)amino]-L-phenylalanine L-sarcolysin phenylalanine mustard L-sarcolysine alanine nitrogen mustard sarcoclorin WR-19813 phenylalanine mustard p-di(chloroethyl)amino-L-phenylalanine |
|
| CAS Registry |
148-82-3 |
|
| cui |
C1513105 C1522636 C0025444 C0591063 C0733456 C0025241 C1522637 |
|
| DATE FIRST PUBLISHED |
2016-02-25 |
|
| Date last modified |
2018-02-14 |
|
| definition |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C633" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C633" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C633 |
|
| notation |
CDR0000779085 |
|
| NSC Code |
8806 241286 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
melphalan |
|
| tui |
T109 T116 T121 |