loading...| Preferred Name |
alpha-tocopherol |
|
| Synonyms |
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol |
|
| Definitions |
A naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74960" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C74960" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000775583 |
|
| altLabel |
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol |
|
| CAS Registry |
59-02-9 |
|
| cui |
C0969677 |
|
| DATE FIRST PUBLISHED |
2015-09-14 |
|
| Date last modified |
2015-09-14 |
|
| definition |
A naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74960" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C74960" NCI Thesaurus) |
|
| NCI ID |
C74960 |
|
| notation |
CDR0000775583 |
|
| NSC Code |
20812 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
alpha-tocopherol |
|
| tui |
T109 T127 T121 |