Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

lenapenem

Synonyms

carbapenem

Definitions

A broad-spectrum, carbapenem antibiotic with bactericidal activity. Lenapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This inhibition weakens the bacterial cell wall and leads to lytic cell death in a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81662" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C81662" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000761707

altLabel

carbapenem

(+)-(4R,5S,6S)-6-((R)-1-hydroxyethyl)-3-(((3S,5S)-5-((R)-1-hydroxy-3-(methylamino)propyl)-3-pyrrolidinyl)thio)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

CAS Registry

149951-16-6

cui

C0006968

DATE FIRST PUBLISHED

2014-06-03

Date last modified

2014-08-13

definition

A broad-spectrum, carbapenem antibiotic with bactericidal activity. Lenapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This inhibition weakens the bacterial cell wall and leads to lytic cell death in a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81662" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C81662" NCI Thesaurus)

NCI ID

C81662

notation

CDR0000761707

ORIG STY

Drug/agent

prefLabel

lenapenem

tui

T109

T195

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