loading...| Preferred Name |
chlorogenic acid |
|
| Synonyms |
5-O-(3,4-dihydroxycinnamoyl)-L-quinic acid |
|
| Definitions |
A polyphenol and the ester of caffeic acid and quinic acid that is found in coffee and black tea, with potential antioxidant and chemopreventive activities. Chlorogenic acid scavenges free radicals, which inhibits DNA damage and may protect against the induction of carcinogenesis. In addition, this agent may upregulate the expression of genes involved in the activation of the immune system and enhance activation and proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic acid also inhibits the activity of matrix metalloproteinases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C116073" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C116073" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000761171 |
|
| altLabel |
5-O-(3,4-dihydroxycinnamoyl)-L-quinic acid 3-caffeoylquinic acid |
|
| CAS Registry |
327-97-9 |
|
| cui |
C0008240 |
|
| DATE FIRST PUBLISHED |
2014-05-15 |
|
| Date last modified |
2014-08-13 |
|
| definition |
A polyphenol and the ester of caffeic acid and quinic acid that is found in coffee and black tea, with potential antioxidant and chemopreventive activities. Chlorogenic acid scavenges free radicals, which inhibits DNA damage and may protect against the induction of carcinogenesis. In addition, this agent may upregulate the expression of genes involved in the activation of the immune system and enhance activation and proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic acid also inhibits the activity of matrix metalloproteinases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C116073" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C116073" NCI Thesaurus) |
|
| NCI ID |
C116073 |
|
| notation |
CDR0000761171 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
chlorogenic acid |
|
| tui |
T109 T123 |