Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

phenprocoumon

Synonyms

3-(alpha-phenylpropyl)-4-hydroxycoumarin

Definitions

An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66374" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66374" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000750561

altLabel

3-(alpha-phenylpropyl)-4-hydroxycoumarin

Liquamar

2H-1-benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-

CAS Registry

435-97-2

cui

C0918267

C0031444

DATE FIRST PUBLISHED

2013-06-19

Date last modified

2013-07-10

definition

An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66374" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66374" NCI Thesaurus)

LT

TRD

NCI ID

C66374

notation

CDR0000750561

ORIG STY

Drug/agent

prefLabel

phenprocoumon

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D010644 MESH CUI
http://purl.bioontology.org/ontology/ATC/B01AA04 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/59488002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-A6545 SNMI CUI
http://purl.bioontology.org/ontology/VANDF/4018525 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/8150 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/59488002 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/LP33034-7 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005930 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/D010644 MESH CUI
http://purl.bioontology.org/ontology/NDDF/002086 NDDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU016364 LOINC CUI
http://purl.bioontology.org/ontology/MSHFRE/D010644 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146847 NDFRT CUI
http://www.drugbank.ca/drugs/DB00946 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031444 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/B01AA04 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D010644 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/59488002 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66374 NCIT LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6545 SNMI LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50438 NIFSTD LOOM
http://purl.bioontology.org/ontology/VANDF/4018525 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010644 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907028810675723 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C66374 BERO LOOM
http://purl.bioontology.org/ontology/RXNORM/8150 RXNORM LOOM
http://bmi.utah.edu/ontologies/peontology/C0031444 PE LOOM
http://purl.bioontology.org/ontology/LNC/LP33034-7 LOINC LOOM
https://go.drugbank.com/drugs/DB00946 MDM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017665 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9606 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D010644 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002086 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016364 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.446.520.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0011632 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.446.520.750 RH-MESH LOOM
http://purl.jp/bio/4/id/200906030531608774 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146847 NDFRT LOOM